Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB-96 trial Academic Article uri icon

Overview

MeSH Major

  • Adrenocorticotropic Hormone
  • Brain Neoplasms
  • Human Growth Hormone
  • Hypothyroidism
  • Neoplasms, Germ Cell and Embryonal
  • Spinal Cord
  • Thyrotropin

abstract

  • Pediatric patients with CNS embryonal tumors are at high risk for treatment-related hormone deficiencies. GHD and primary hypothyroidism were diagnosed in a majority of subjects relatively soon after the completion of therapy. Radiation dose to the hypothalamus in excess of 42 Gy was associated with an increase in the risk of developing TSH deficiency.

publication date

  • March 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2008.13.5293

PubMed ID

  • 18309946

Additional Document Info

start page

  • 1112

end page

  • 8

volume

  • 26

number

  • 7