Therapeutic cloning in individual parkinsonian mice Academic Article uri icon

Overview

MeSH Major

  • Embryonic Stem Cells
  • Parkinsonian Disorders

abstract

  • Cell transplantation with embryonic stem (ES) cell progeny requires immunological compatibility with host tissue. 'Therapeutic cloning' is a strategy to overcome this limitation by generating nuclear transfer (nt)ES cells that are genetically matched to an individual. Here we establish the feasibility of treating individual mice via therapeutic cloning. Derivation of 187 ntES cell lines from 24 parkinsonian mice, dopaminergic differentiation, and transplantation into individually matched host mice showed therapeutic efficacy and lack of immunological response.

publication date

  • April 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2786166

Digital Object Identifier (DOI)

  • 10.1038/nm1732

PubMed ID

  • 18376409

Additional Document Info

start page

  • 379

end page

  • 81

volume

  • 14

number

  • 4