Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation Academic Article uri icon

Overview

MeSH Major

  • DNA Methylation
  • Genomic Imprinting
  • Kruppel-Like Transcription Factors
  • Ovarian Neoplasms
  • Promoter Regions, Genetic
  • rho GTP-Binding Proteins

abstract

  • Loss of expression of the growth-inhibitory imprinted genes ARHI and PEG3 through promoter methylation, LOH, and other mechanisms may stimulate clonogenic growth and contribute to the pathogenesis of a majority of ovarian cancers.

publication date

  • April 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/cncr.23323

PubMed ID

  • 18286529

Additional Document Info

start page

  • 1489

end page

  • 502

volume

  • 112

number

  • 7