Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Lung Neoplasms
  • Mutation
  • Protein Kinase Inhibitors
  • Receptor, Epidermal Growth Factor

abstract

  • These new mouse models of mutant EGFR-dependent lung adenocarcinomas provide insight into clinical observations. The models should also be useful for developing improved therapies for patients with lung cancers harboring EGFR(T790M) alone or in conjunction with drug-sensitive EGFR kinase domain mutations.

publication date

  • August 29, 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1950079

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0000810

PubMed ID

  • 17726540

Additional Document Info

start page

  • e810

volume

  • 2

number

  • 8