Tumour growth inhibition by an imidazoquinoline is associated with c-Myc down-regulation in urothelial cell carcinoma Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Transitional Cell
  • Proto-Oncogene Proteins c-myc
  • Toll-Like Receptor 7
  • Urinary Bladder Neoplasms

abstract

  • Imidazoquinolines can inhibit c-Myc expression and directly affect cell growth and tumorigenesis of bladder cancer cells, independent of an immune response. These direct effects might be synergistic with previously described immunogenic actions of imidazoquinolines. Our findings could broaden the potential application of imidazoquinoline therapy beyond dermatological malignancies, and further clinical studies are warranted.

publication date

  • April 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1111/j.1464-410X.2008.07459.x

PubMed ID

  • 18241249

Additional Document Info

start page

  • 894

end page

  • 901

volume

  • 101

number

  • 7