Studies toward diazonamide A: Development of a hetero-pinacol macrocyclization cascade for the construction of the bis-macrocyclic framework of the originally proposed structure Academic Article uri icon

Overview

MeSH Major

  • Heterocyclic Compounds, 4 or More Rings
  • Oxazoles

abstract

  • In this article, we describe further studies toward the originally proposed structure of diazonamide A (1). After confronting a number of failures in synthesizing the heterocyclic core of that structure, success was finally realized through the development of a novel hetero-pinacol-based macrocyclization cascade sequence. Subsequent elaboration led to an advanced compound bearing both of the 12-membered rings of the target molecule. In addition, preliminary biological studies with intermediates and simplified analogues obtained via the developed sequences are also described.

publication date

  • August 18, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1021/ja040091q

PubMed ID

  • 15303893

Additional Document Info

start page

  • 10174

end page

  • 82

volume

  • 126

number

  • 32