Acute leukemia immunohistochemistry: A systematic diagnostic approach Review uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Leukemia

abstract

  • Immunophenotyping of blasts using an immunohistochemical approach to lymphoid and myeloid malignancies is presented. Initial and subsequent additional antibody panels are suggested to confirm or exclude each possibility in the differential diagnosis and a general strategy for diagnostic evaluation is discussed. Although the use of immunohistochemistry alone is limited and evaluation by flow cytometry and genetic studies is highly recommended, unavoidable situations requiring analysis of formalin-fixed tissue specimens arise. When performed in an optimized laboratory and combined with a careful morphologic examination, the immunohistochemical approach represents a useful laboratory tool for classifying various leukemias.

publication date

  • March 2008

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 18318587

Additional Document Info

start page

  • 462

end page

  • 75

volume

  • 132

number

  • 3