A Catalytic Role for Proangiogenic Marrow-Derived Cells in Tumor Neovascularization Article uri icon


MeSH Major

  • Bone Marrow Cells
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Matrix Metalloproteinase 9
  • Monocytes
  • Myeloid Cells
  • Neoplasms, Experimental
  • Neovascularization, Pathologic


  • Small numbers of proangiogenic bone marrow-derived cells (BMDCs) can play pivotal roles in tumor progression. In this issue of Cancer Cell, two papers, utilizing different tumor angiogenesis models, both find that activated MMP-9 delivered by BMDCs modulates neovessel remodeling, thereby promoting tumor growth. The changes in microvascular anatomy induced by MMP-9-expressing BMDCs are strikingly different between the preirradiated tumor vascular bed model employed by Ahn and Brown and the invasive glioblastoma model utilized by Du et al., likely mirroring the complexity of the real tumor microenvironment and the intricacy of roles of different BMDC populations in mediating tumor neoangiogenesis.

publication date

  • March 11, 2008



  • Article


Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2008.02.016

Additional Document Info

start page

  • 181

end page

  • 3


  • 13


  • 3