Antiretroviral drug-based microbicides to prevent HIV-1 sexual transmission Review uri icon

Overview

MeSH Major

  • Anti-Retroviral Agents
  • HIV Infections
  • HIV-1

abstract

  • The development of a vaginal (and perhaps a rectal) microbicide would be of major benefit for slowing the global spread of human immunodeficiency virus type 1 (HIV-1). A microbicide is a gel or related device that, when inserted vaginally or rectally, acts to prevent infection of a woman or a man by HIV-1 during sexual intercourse. A practical microbicide must be not only effective, safe, and user-friendly but also economically affordable in the developing world. To date, the performance of microbicide candidates in efficacy trials has been disappointing, but next-generation concepts now in or approaching clinical trials offer improved prospects for efficacy. The most plausible approaches involve topical application of antiretroviral agents with specific activity against HIV-1, compounds similar to drugs used to treat HIV-1 infection. How these inhibitors are applied may also be critical, with sustained-release formulations and vaginal ring delivery systems now becoming a high priority.

publication date

  • February 28, 2008

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1146/annurev.med.59.061206.112737

PubMed ID

  • 17892435

Additional Document Info

start page

  • 455

end page

  • 71

volume

  • 59