Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation Academic Article uri icon

Overview

MeSH Major

  • Brain
  • Cardiopulmonary Resuscitation
  • Heart Arrest
  • Protein Phosphatase 2

abstract

  • Protein phosphatase-2A (PP-2A) interacts with several regulators of cell death pathways and is therefore a potential component of signaling pathways linking global cerebral ischemia to cell death. Using a novel procedure to quantify PP-2A activity, we find that cardiac arrest with resuscitation and reperfusion leads to activation of PP-2A by 1.6-fold in pig brain extract and by 3.4-fold after partial purification of PP-2A. This is the first demonstration of PP-2A activation in a clinically relevant model of transient global cerebral ischemia. These results suggest that inhibition of PP-2A activity may be neuroprotective in global cerebral ischemia.

publication date

  • March 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1007/s11011-007-9074-1

PubMed ID

  • 18197471

Additional Document Info

start page

  • 95

end page

  • 104

volume

  • 23

number

  • 1