Dendritic cells and cytokines in human inflammatory and autoimmune diseases Review uri icon

Overview

MeSH Major

  • Autoimmune Diseases
  • Cytokines
  • Dendritic Cells
  • Inflammation

abstract

  • Dendritic cells (DCs) produce cytokines and are susceptible to cytokine-mediated activation. Thus, interaction of resting immature DCs with TLR ligands, for example nucleic acids, or with microbes leads to a cascade of pro-inflammatory cytokines and skewing of T cell responses. Conversely, several cytokines are able to trigger DC activation (maturation) via autocrine, for example TNF and plasmacytoid DCs, and paracrine, for example type I IFN and myeloid DCs, pathways. By controlling DC activation, cytokines regulate immune homeostasis and the balance between tolerance and immunity. The increased production and/or bioavailability of cytokines and associated alterations in DC homeostasis have been implicated in various human inflammatory and autoimmune diseases. Targeting these cytokines with biological agents as already is the case with TNF and IL-1 represents a success of immunology and the coming years will expand the range of cytokines as therapeutic targets in autoinflammatory and autoimmune pathology.

publication date

  • February 2008

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC2413068

Digital Object Identifier (DOI)

  • 10.1016/j.cytogfr.2007.10.004

PubMed ID

  • 18258476

Additional Document Info

start page

  • 41

end page

  • 52

volume

  • 19

number

  • 1