Pulsed high-intensity focused ultrasound enhances uptake of radiolabeled monoclonal antibody to human epidermoid tumor in nude mice Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Squamous Cell
  • Phonophoresis

abstract

  • This study demonstrates that pulsed-HIFU significantly enhances the delivery of (111)In-MX-B3 in human epidermoid tumors xenografted in nude mice. The results of this pilot study warrant further evaluation of other treatment regimens, such as repeated HIFU exposures for greater delivery enhancement of antibodies labeled with cytotoxic radioisotopes or pulsed-HIFU exposure in addition to a combined therapy of (90)Y-B3 and taxol to enhance the synergistic effect.

publication date

  • February 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.2967/jnumed.107.046888

PubMed ID

  • 18199622

Additional Document Info

start page

  • 295

end page

  • 302

volume

  • 49

number

  • 2