Phase I study of troxacitabine administered by continuous infusion in subjects with advanced solid malignancies Academic Article uri icon

Overview

MeSH Major

  • Cytosine
  • Dioxolanes
  • Neoplasm Invasiveness
  • Neoplasms

abstract

  • Administration of troxacitabine by continuous infusion achieved the prospectively defined target plasma concentration. Pharmacokinetics (PK) modeling coupled with real-time PK assessment was an efficient approach to conduct hypothesis-driven phase I trials.

publication date

  • February 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3557502

Digital Object Identifier (DOI)

  • 10.1093/annonc/mdm572

PubMed ID

  • 18245131

Additional Document Info

start page

  • 374

end page

  • 9

volume

  • 19

number

  • 2