Bax and Bak Do Not Exhibit Functional Redundancy in Mediating Radiation-Induced Endothelial Apoptosis in the Intestinal Mucosa Academic Article uri icon

Overview

MeSH Major

  • Apoptosis
  • Endothelial Cells
  • Intestinal Mucosa
  • Intestine, Small
  • bcl-2 Homologous Antagonist-Killer Protein
  • bcl-2-Associated X Protein

abstract

  • The data indicate that Bax and Bak have nonredundant functional roles in the apoptotic response of the irradiated intestinal endothelium. The observation that Bax deficiency and Bak deficiency also protect crypts in the microcolony assay provides strong evidence that the microvascular apoptotic component is germane to the mechanism of radiation-induced damage to mouse intestines, regulating reproductive cell death of crypt stem cell clonogens.

publication date

  • March 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.ijrobp.2007.11.043

PubMed ID

  • 18191336

Additional Document Info

start page

  • 804

end page

  • 15

volume

  • 70

number

  • 3