Evaluation of JAK2V617F in B and T cell neoplasms: Identification of JAK2V617F mutation of undetermined significance (JMUS) in the bone marrow of three individuals Academic Article uri icon

Overview

MeSH Major

  • Bone Marrow
  • Janus Kinase 2
  • Lymphoma, B-Cell
  • Mutation, Missense
  • Neoplasm Proteins
  • Point Mutation

abstract

  • These findings suggest that JAK2(V617F) arises in the bone marrow of individuals before clinical manifestation of any myeloid disorders. Presence of JAK2(V617F) in bone marrow might therefore increase the risk of future MPD development, just as monoclonal gammopathy of undetermined significance (MGUS) increases the risk of multiple myeloma. We term this phenomenon 'JAK2(V617F) of undetermined significance' (JMUS). Its clinical significance remains to be determined. To our knowledge, these findings represent the first identification of JAK2(V617F) in the bone marrow of patients without myeloid malignancies.

publication date

  • January 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1159/000111532

PubMed ID

  • 18032883

Additional Document Info

start page

  • 209

end page

  • 14

volume

  • 118

number

  • 4