cT3N0 rectal cancer: Potential overtreatment with preoperative chemoradiotherapy is warranted Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Rectal Neoplasms

abstract

  • The accuracy of preoperative ERUS/MRI for staging mid to distal cT3N0 rectal cancer is limited because 22% of patients have undetected mesorectal LN involvement despite CMT. Therefore, ERUS-/MRI-staged T3N0 rectal cancer patients should continue to receive preoperative CMT. Although 18% may be overstaged and therefore overtreated, our data suggest that an even larger number would be understaged and require postoperative CMT, which is associated with significantly inferior local control, higher toxicity, and worse functional outcome.

publication date

  • January 20, 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2007.13.5434

PubMed ID

  • 18202411

Additional Document Info

start page

  • 368

end page

  • 73

volume

  • 26

number

  • 3