Shifting the landscape: The role of IDH inhibitors in glioma cell fate. Academic Article uri icon

Overview

abstract

  • In this issue of Cancer Cell, Spitzer and colleagues demonstrate the role of IDH inhibitors on IDHmutant gliomas in reducing proliferation and enhancing cell differentiation toward an astrocytic-like state, thus altering neurodevelopmental pathways. Despite clinical promise, unresolved questions regarding mechanisms of action and resistance underline the need for further research for treatment optimization.

publication date

  • March 29, 2024

Research

keywords

  • Brain Neoplasms
  • Glioma
  • Isocitrate Dehydrogenase

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2024.02.008

PubMed ID

  • 38579726