Failure of frontolimbic inhibitory function in the context of negative emotion in borderline personality disorder. Academic Article Article uri icon

Overview

MeSH

  • Adult
  • Brain Mapping
  • Choice Behavior
  • Female
  • Functional Laterality
  • Gyrus Cinguli
  • Humans
  • Image Processing, Computer-Assisted
  • Male
  • Middle Aged
  • Personality Inventory
  • Reaction Time
  • Reading
  • Verbal Behavior

MeSH Major

  • Amygdala
  • Borderline Personality Disorder
  • Emotions
  • Inhibition (Psychology)
  • Limbic System
  • Magnetic Resonance Imaging
  • Prefrontal Cortex

abstract

  • The authors sought to test the hypothesis that in patients with borderline personality disorder, the ventromedial prefrontal cortex and associated regions would not be activated during a task requiring motor inhibition in the setting of negative emotion. Such a finding would provide a plausible neural basis for the difficulty borderline patients have in modulating their behavior during negative emotional states and a potential marker for treatment interventions. A specifically designed functional magnetic resonance imaging (fMRI) activation probe was used, with statistical parametric mapping analyses, to test hypotheses concerning decreased prefrontal inhibitory function in the context of negative emotion in patients with borderline personality disorder (N=16) and healthy comparison subjects (N=14). 3-T fMRI scanning was used to study brain activity while participants performed an emotional linguistic go/no-go task. Analyses confirmed that under conditions associated with the interaction of behavioral inhibition and negative emotion, borderline patients showed relatively decreased ventromedial prefrontal activity (including medial orbitofrontal and subgenual anterior cingulate) compared with healthy subjects. In borderline patients, under conditions of behavioral inhibition in the context of negative emotion, decreasing ventromedial prefrontal and increasing extended amygdalar-ventral striatal activity correlated highly with measures of decreased constraint and increased negative emotion, respectively. These findings suggest specific frontolimbic neural substrates associated with core clinical features of emotional and behavioral dyscontrol in borderline personality disorder.

publication date

  • December 2007

has subject area

  • Adult
  • Amygdala
  • Borderline Personality Disorder
  • Brain Mapping
  • Choice Behavior
  • Emotions
  • Female
  • Functional Laterality
  • Gyrus Cinguli
  • Humans
  • Image Processing, Computer-Assisted
  • Inhibition (Psychology)
  • Limbic System
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Personality Inventory
  • Prefrontal Cortex
  • Reaction Time
  • Reading
  • Verbal Behavior

Research

keywords

  • Comparative Study
  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1176/appi.ajp.2007.06010126

PubMed ID

  • 18056238

Additional Document Info

start page

  • 1832

end page

  • 1841

volume

  • 164

number

  • 12