Dopamine transporter genotype conveys familial risk of attention-deficit/ hyperactivity disorder through striatal activation
Attention Deficit Disorder with Hyperactivity
Dopamine Plasma Membrane Transport Proteins
Magnetic Resonance Imaging
These preliminary results suggest that the DAT1 gene effects in the striatum are involved in translating the genetic risk of ADHD into a neurobiological substrate. As such, this study represents a first step in elucidating the neurobiological mechanisms underlying genetic influences in ADHD. Furthermore, these results may contribute to long-term possibilities for the development of new treatments: If the DAT1 genotype has differential effects on striatal activation, then it may be useful as a surrogate endpoint in individualized treatments targeting genotype/functional magnetic resonance imaging activation profiles.