Dopamine transporter genotype conveys familial risk of attention-deficit/ hyperactivity disorder through striatal activation Academic Article uri icon

Overview

MeSH Major

  • Attention Deficit Disorder with Hyperactivity
  • Corpus Striatum
  • Dopamine Plasma Membrane Transport Proteins
  • Genotype
  • Magnetic Resonance Imaging

abstract

  • These preliminary results suggest that the DAT1 gene effects in the striatum are involved in translating the genetic risk of ADHD into a neurobiological substrate. As such, this study represents a first step in elucidating the neurobiological mechanisms underlying genetic influences in ADHD. Furthermore, these results may contribute to long-term possibilities for the development of new treatments: If the DAT1 genotype has differential effects on striatal activation, then it may be useful as a surrogate endpoint in individualized treatments targeting genotype/functional magnetic resonance imaging activation profiles.

publication date

  • January 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/chi.0b013e31815a5f17

PubMed ID

  • 18174826

Additional Document Info

start page

  • 61

end page

  • 7

volume

  • 47

number

  • 1