Prophylactic low-dose aspirin is effective antithrombotic therapy for combination treatments of thalidomide or lenalidomide in myeloma. Academic Article uri icon

Overview

MeSH

  • Adult
  • Aged
  • Drug Therapy, Combination
  • Female
  • Heparin, Low-Molecular-Weight
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies

MeSH Major

  • Antineoplastic Agents
  • Aspirin
  • Multiple Myeloma
  • Thalidomide
  • Thrombosis

abstract

  • Multiple myeloma (MM) patients have a propensity for thromboembolic events (TE), and treatment with thalidomide/dexamethasone or lenalidomide/dexamethasone increases this risk. This report describes the use of low-dose aspirin (81 mg) as primary thromboprophylaxis in three series of MM patients receiving thalidomide or lenalidomide with other drugs. In the first regimen (clarithromycin, thalidomide, dexamethasone), initiation of low-dose aspirin negated the occurrence of any further TE. In a second study, prophylactic aspirin given with thalidomide/dexamethasone resulted in a rate of TE similar to that seen with dexamethasone alone (without aspirin). A third study (n = 72) evaluated thrombosis rates with aspirin and a lenalidomide-containing regimen (clarithromycin, lenalidomide, dexamethasone). Of nine occurrences of thromboembolism, five were associated with aspirin interruption or poor compliance. Low-dose aspirin appears to reduce the incidence of thrombosis with these regimens. Routine use of aspirin as antithrombotic prophylaxis in MM patients receiving immunomodulatory drugs with corticosteroids is warranted.

publication date

  • December 2007

has subject area

  • Adult
  • Aged
  • Antineoplastic Agents
  • Aspirin
  • Drug Therapy, Combination
  • Female
  • Heparin, Low-Molecular-Weight
  • Humans
  • Male
  • Middle Aged
  • Multiple Myeloma
  • Retrospective Studies
  • Thalidomide
  • Thrombosis

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1080/10428190701647887

PubMed ID

  • 18067007

Additional Document Info

start page

  • 2330

end page

  • 2337

volume

  • 48

number

  • 12