Convulsant drug action on neuronally isolated cerebral cortex Academic Article uri icon

Overview

MeSH Major

  • Central Nervous System Stimulants
  • Cerebral Cortex
  • Convulsants
  • Isoniazid
  • Pharmacology
  • Research
  • Strychnine
  • Thiosemicarbazones

abstract

  • After topical application of thiosemicarbazide, semicarbazide, or isoniazid to the surface of an isolated region of cortex, convulsive responses to electrical stimulation appeared only after a finite number of normal responses had been elicited, and disappeared again if stimulation was interrupted for about 10 minutes. With any of the other convulsant drugs tested, development of the convulsive pattern was independent of whether or not the cortex was stimulated. The two groups of drugs evidently have dijferent modes of action.

publication date

  • December 1963

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 14069231

Additional Document Info

start page

  • 973

end page

  • 5

volume

  • 142

number

  • 3594