Increased sensitivity of lymphocytes from people over 65 to cell cycle arrest and chromosomal damage Academic Article Article uri icon

Overview

MeSH Major

  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Dementia
  • Down Syndrome

abstract

  • Several lines of evidence suggest that there might be immunologic cross-reactivity between the thyroid plasma membrane in humans and antigenic determinants in the enteric pathogen Yersinia enterocolitica. Studies were therefore performed to determine whether Y. enterocolitica, like the thyroid membrane, contains a thyrotropin binding site. A saturable binding site for bovine thyrotropin was indeed demonstrable, particularly in preparations of the organism that have been treated with ethylenediaminetetraacetate and lysozyme. Hormonal specificity of the binding site, as judged from the inhibition of binding of 125I-labeled bovine thyrotropin, was similar to that of the thyrotropin receptor in human thyroid tissue.

publication date

  • December 1983

Research

keywords

  • Academic Article

Identity

PubMed ID

  • 6828861

Additional Document Info

start page

  • 1331

end page

  • 3

volume

  • 219

number

  • 4590