Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Cytokines
  • Genetic Predisposition to Disease
  • Glioma
  • Polymorphism, Single Nucleotide

abstract

  • A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma.

publication date

  • December 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1093/carcin/bgm210

PubMed ID

  • 17916900

Additional Document Info

start page

  • 2543

end page

  • 7

volume

  • 28

number

  • 12