p53 regulates the mitochondrial immune checkpoint. Academic Article uri icon

Overview

abstract

  • Mitochondrial outer membrane permeabilization (MOMP) is crucial for the cytosolic accumulation of mitochondrial DNA (mtDNA) species that are required to jumpstart innate and adaptive immunity. Recent data reported by Ghosh et al. suggest that tumor protein p53 regulates MOMP-dependent type I interferon (IFN) production, not only via MOMP-promoting effects, but also by directing mtDNA-degrading exonucleases to proteasomal processing.

publication date

  • March 16, 2023

Research

keywords

  • Mitochondria
  • Tumor Suppressor Protein p53

Identity

Scopus Document Identifier

  • 85150041805

Digital Object Identifier (DOI)

  • 10.1016/j.it.2023.03.001

PubMed ID

  • 36933950

Additional Document Info

volume

  • 44

issue

  • 4