Phase II study of uracil-tegafur with leucovorin in elderly (≥ 75 years old) patients with colorectal cancer: ECOG 1299
Antineoplastic Combined Chemotherapy Protocols
The results of this trial support the efficacy of oral UFT/LV in elderly patients with colorectal cancer. The regimen is tolerated moderately well overall, particularly as compared with other fluoropyrimidine regimens, although there is increased GI toxicity in the most elderly. These results suggest that studies using newer oral fluoropyrimidine analogs should be investigated in this patient population.