Phase II study of uracil-tegafur with leucovorin in elderly (≥ 75 years old) patients with colorectal cancer: ECOG 1299 Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Antineoplastic Combined Chemotherapy Protocols
  • Colorectal Neoplasms

abstract

  • The results of this trial support the efficacy of oral UFT/LV in elderly patients with colorectal cancer. The regimen is tolerated moderately well overall, particularly as compared with other fluoropyrimidine regimens, although there is increased GI toxicity in the most elderly. These results suggest that studies using newer oral fluoropyrimidine analogs should be investigated in this patient population.

publication date

  • December 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2006.10.4521

PubMed ID

  • 18048821

Additional Document Info

start page

  • 5397

end page

  • 402

volume

  • 25

number

  • 34