Microarray-based identification of novel biomarkers in IL-1-mediated diseases Review uri icon

Overview

MeSH Major

  • Biomarkers
  • Gene Expression Profiling
  • Immune System Diseases
  • Inflammation
  • Interleukin-1
  • Receptors, Interleukin-1

abstract

  • Interleukin 1b (IL-1b) is emerging as mediator of a wide range of human diseases. Availability of IL-1 blockers that result in clinical benefits to patients with these diseases is creating a demand for biomarkers to diagnose as well as to predict and follow responses to therapy. Blood gene expression profiling can be used to identify such biomarkers. This review will summarize recent studies in the field and will discuss some of the challenges raised by the use of this technology in biomarker discovery.

publication date

  • December 2007

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC2747489

Digital Object Identifier (DOI)

  • 10.1016/j.coi.2007.10.003

PubMed ID

  • 18036805

Additional Document Info

start page

  • 623

end page

  • 32

volume

  • 19

number

  • 6