Toll-Like Receptor-4 Promotes the Development of Colitis-Associated Colorectal Tumors Academic Article uri icon

Overview

MeSH Major

  • Colitis
  • Colorectal Neoplasms
  • Toll-Like Receptor 4

abstract

  • TLR4 signaling is critical for colon carcinogenesis in chronic colitis. TLR4 activation appears to promote the development of colitis-associated cancer by mechanisms including enhanced Cox-2 expression and increased EGFR signaling. Inhibiting TLR4 signaling may be useful in the prevention or treatment of colitis-associated cancer.

publication date

  • December 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2180834

Digital Object Identifier (DOI)

  • 10.1053/j.gastro.2007.09.008

PubMed ID

  • 18054559

Additional Document Info

start page

  • 1869

end page

  • 81

volume

  • 133

number

  • 6