Toll-Like Receptor-4 Promotes the Development of Colitis-Associated Colorectal Tumors
Toll-Like Receptor 4
TLR4 signaling is critical for colon carcinogenesis in chronic colitis. TLR4 activation appears to promote the development of colitis-associated cancer by mechanisms including enhanced Cox-2 expression and increased EGFR signaling. Inhibiting TLR4 signaling may be useful in the prevention or treatment of colitis-associated cancer.