Clinical strategies to enhance T cell reconstitution Review uri icon

Overview

MeSH Major

  • T-Lymphocytes

abstract

  • Strategies to enhance T cell recovery are of increasing clinical importance to overcome long lasting T cell deficiencies, which occur in association with infections, autoimmunity and chemo/radiotherapy as well as aging of the immune system. In this review we discuss those strategies that are close to or in the clinic. Interleukin-7, sex steroid modulation, keratinocyte growth factor, growth hormone and cellular therapies using ex vivo generated T-cell precursors are currently being tested in recipients of a hematopoietic stem cell transplantation and patients with malignancies or HIV/AIDS.

publication date

  • October 2007

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC2696308

Digital Object Identifier (DOI)

  • 10.1016/j.smim.2007.08.001

PubMed ID

  • 17964803

Additional Document Info

start page

  • 289

end page

  • 96

volume

  • 19

number

  • 5