T cell-independent abscopal responses to radiotherapy. Academic Article uri icon

Overview

abstract

  • When used according to specific dose/fractionation schedules, focal radiotherapy can elicit a systemic anticancer immune response that limits the growth of distant, non-irradiated tumors. Recent data suggest that, at least in some settings, intratumoral macrophages can be educated by CD47 blockage to promote such an 'abscopal' response independent of CD8+ T cells.

publication date

  • December 20, 2022

Research

keywords

  • CD8-Positive T-Lymphocytes
  • Neoplasms

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.trecan.2022.12.005

PubMed ID

  • 36543690