Validation of Single-Item Linear Analog Scale Assessment of Quality of Life in Neuro-Oncology Patients Academic Article uri icon


MeSH Major

  • Brain Neoplasms
  • Cost of Illness
  • Glioma
  • Psychometrics
  • Quality of Life


  • Assessment of patient quality of life (QOL) requires balancing the details provided by multi-item assessments with the reduced burden of single-item assessments. In this project, we investigated the psychometric properties of single-item Linear Analog Scale Assessments (LASAs) for patients with newly diagnosed high-grade gliomas. Measures included QOL LASAs (overall, physical, emotional, spiritual, intellectual), Symptom Distress Scale (SDS), Profile of Mood States (POMS; overall, confusion, fatigue), and Functional Assessment of Cancer Therapy-Brain (FACT-Br; overall, brain, physical, emotional). Associations of LASA measures with SDS, POMS, and FACT-Br domains and with Eastern Cooperative Oncology Group performance score (PS) and Mini-Mental State Examination (MMSE) were assessed. Repeated measures ANOVA models compared the change over time of LASAs and SDS, POMS, and FACT-Br. Two hundred five patients completed the assessments across three time points. To allow comparison across measures, all scores were converted to a scale of 0-100, with higher scores indicating better QOL. LASA mean scores ranged from 60 to 78; SDS, POMS, and FACT-Br ranged from 62 to 81. FACT-Br physical (P<0.001) and POMS fatigue subscale (P=0.005) decreased over time, as did LASA physical (P=0.08). LASA scales were strongly associated with corresponding scales on SDS, POMS, and FACT-Br (0.44

publication date

  • December 2007



  • Academic Article



  • eng

PubMed Central ID

  • PMC2732111

Digital Object Identifier (DOI)

  • 10.1016/j.jpainsymman.2007.01.016

PubMed ID

  • 17703910

Additional Document Info

start page

  • 628

end page

  • 38


  • 34


  • 6