Peginterferon alfa-2b and Weight-Based or Flat-Dose Ribavirin in Chronic Hepatitis C Patients: A Randomized Trial Academic Article uri icon

Overview

MeSH Major

  • Antiviral Agents
  • Hepatitis C
  • Interferon-alpha
  • Ribavirin

abstract

  • PEG-IFN alfa-2b plus weight-based RBV is more effective than flat-dose RBV, particularly in genotype 1 patients, providing equivalent efficacy across all weight groups. RBV 1400 mg/day is appropriate for patients 105 to 125 kg. For genotype 2/3 patients, 24 weeks of treatment with flat-dose RBV is adequate; no evidence of additional benefit of extending treatment to 48 weeks was demonstrated.

authors

publication date

  • October 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/hep.21932

PubMed ID

  • 17894303

Additional Document Info

start page

  • 971

end page

  • 81

volume

  • 46

number

  • 4