The role of serpinb9/serine protease inhibitor 6 in preventing granzyme B-dependent hepatotoxicity Academic Article uri icon

Overview

MeSH Major

  • Granzymes
  • Hepatitis, Viral, Animal
  • Hepatocytes
  • Killer Cells, Natural
  • Membrane Proteins
  • Serine Endopeptidases
  • Serpins
  • T-Lymphocytes, Cytotoxic

abstract

  • These results indicate that the regulated expression of SPI-6 in hepatocytes during viral infection or following noninfectious causes of liver injury protects hepatocytes against excessively vigorous granzyme B-dependent killing but may also delay immune clearance of virally infected hepatocytes.

publication date

  • November 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2659535

Digital Object Identifier (DOI)

  • 10.1002/hep.21820

PubMed ID

  • 17685438

Additional Document Info

start page

  • 1530

end page

  • 40

volume

  • 46

number

  • 5