Antiproteinase 3 antineutrophil cytoplasmic antibodies and disease activity in Wegener granulomatosis
Antibodies, Antineutrophil Cytoplasmic
Granulomatosis with Polyangiitis
Pro-PR3-ANCA is no better than mature-PR3-ANCA as a measure of Wegener granulomatosis activity. Decreases in PR3-ANCA levels are not associated with shorter time to remission, and increases are not associated with relapse. These findings suggest that ANCA levels cannot be used to guide immunosuppressive therapy.