Universal dynamics of mitochondrial networks: a finite-size scaling analysis. Academic Article uri icon

Overview

abstract

  • Evidence from models and experiments suggests that the networked structure observed in mitochondria emerges at the critical point of a phase transition controlled by fission and fusion rates. If mitochondria are poised at criticality, the relevant network quantities should scale with the system's size. However, whether or not the expected finite-size effects take place has not been demonstrated yet. Here, we first provide a theoretical framework to interpret the scaling behavior of mitochondrial network quantities by analyzing two conceptually different models of mitochondrial dynamics. Then, we perform a finite-size scaling analysis of real mitochondrial networks extracted from microscopy images and obtain scaling exponents comparable with critical exponents from models and theory. Overall, we provide a universal description of the structural phase transition in mammalian mitochondria.

publication date

  • October 12, 2022

Research

keywords

  • Finite Element Analysis
  • Mitochondrial Dynamics

Identity

PubMed Central ID

  • PMC9556628

Scopus Document Identifier

  • 85139761469

Digital Object Identifier (DOI)

  • 10.1038/s41598-022-14946-9

PubMed ID

  • 36224243

Additional Document Info

volume

  • 12

issue

  • 1