Long-term impact of radiation on the stem cell and oligodendrocyte precursors in the brain Academic Article uri icon

Overview

MeSH Major

  • Brain
  • Oligodendroglia
  • Stem Cells

abstract

  • This study demonstrates that long term radiation injury is associated with irreversible damage to the neural stem cell compartment in the rodent SVZ and loss of oligodendrocyte precursor cells in both rodent and human brain. Delayed onset demyelination precedes focal necrosis and is likely due to the loss of oligodendrocyte precursors and the inability of the stem cell compartment to compensate for this loss.

publication date

  • July 11, 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1913551

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0000588

PubMed ID

  • 17622341

Additional Document Info

start page

  • e588

volume

  • 2

number

  • 7