Effects of drug efflux on convection-enhanced paclitaxel delivery to malignant gliomas: Technical note - Commentary Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Convection
  • Glioma
  • Infusions, Intralesional
  • Paclitaxel

abstract

  • Vd remained high and no adverse effects were seen in Group 3. Sealing the burr hole during CED prevented efflux. The simple measure of sealing seems to increase Vd. These data demonstrate that uncontrolled backflow may have an important impact on CED and must be avoided.

publication date

  • October 2007

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1227/01.NEU.0000298922.77921.F2

Additional Document Info

start page

  • E880

end page

  • 2; discussion E882

volume

  • 61

number

  • 4