Investigation of the role of the base in the synthesis of [18F]FLT. Academic Article uri icon

Overview

MeSH

  • Animals
  • Chromatography, High Pressure Liquid
  • Humans
  • Molecular Structure
  • Positron-Emission Tomography

MeSH Major

  • Dideoxynucleosides
  • Fluorine Radioisotopes
  • Radiopharmaceuticals

abstract

  • The role of the base in the synthesis of 3'-deoxy-3'-[18F]fluorothymidine, [18F]FLT, via nucleophilic substitution of the nosyl group with [18F]fluoride was investigated. The rate of 18F-incorporation into the molecule dramatically changed as a function of the precursor-to-base ratio. In the presence of excess base, the precursor was consumed by elimination before substitution was complete. When the precursor-to-base ratio was optimal, an overall [18F]FLT yield of 30-40% was achieved even if the precursor amount was as small as 8-13 mg.

publication date

  • December 2007

has subject area

  • Animals
  • Chromatography, High Pressure Liquid
  • Dideoxynucleosides
  • Fluorine Radioisotopes
  • Humans
  • Molecular Structure
  • Positron-Emission Tomography
  • Radiopharmaceuticals

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.apradiso.2007.07.013

PubMed ID

  • 17919915

Additional Document Info

start page

  • 1350

end page

  • 1358

volume

  • 65

number

  • 12