Rate and determinants of progression of atherosclerosis in systemic lupus erythematosus
Carotid Artery Diseases
Lupus Erythematosus, Systemic
Atherosclerosis develops or progresses in a substantial minority of SLE patients during short-term followup (10% per year on average). Older age at diagnosis, longer duration of SLE, and higher homocysteine concentration are independently related to progression of atherosclerosis. These findings show that aggressive control of SLE and lowering of homocysteine concentrations are potential means to retard the development and progression of atherosclerosis in SLE.