Global histone modifications predict prognosis of resected non-small-cell lung cancer Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Non-Small-Cell Lung
  • Histones
  • Lung Neoplasms
  • Protein Processing, Post-Translational

abstract

  • The prognostic influence of epigenetic changes involving multiple histones, in particular H2A and H3, is greater in early NSCLC, and evaluation of these changes may help in selecting early-stage NSCLC patients for adjuvant treatment. Our observations provide a rationale for the use of a combination of standard chemotherapy with drugs interacting with histone modifications, such as histone deacetylase inhibitors.

publication date

  • October 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2007.11.2599

PubMed ID

  • 17906200

Additional Document Info

start page

  • 4358

end page

  • 64

volume

  • 25

number

  • 28