Global histone modifications predict prognosis of resected non-small-cell lung cancer
Carcinoma, Non-Small-Cell Lung
Protein Processing, Post-Translational
The prognostic influence of epigenetic changes involving multiple histones, in particular H2A and H3, is greater in early NSCLC, and evaluation of these changes may help in selecting early-stage NSCLC patients for adjuvant treatment. Our observations provide a rationale for the use of a combination of standard chemotherapy with drugs interacting with histone modifications, such as histone deacetylase inhibitors.