Phase I dose-finding study of weekly docetaxel followed by flavopiridol for patients with advanced solid tumors Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Combined Chemotherapy Protocols
  • Flavonoids
  • Neoplasms
  • Piperidines
  • Taxoids

abstract

  • Treatment with weekly, sequential docetaxel followed by flavopiridol is an effective and safe regimen at all flavopiridol dose levels. The pharmacokinetic data indicate that concentrations of flavopiridol that enhance the effects of docetaxel both in vitro and in vivo can be achieved. Clinical activity is encouraging, even in patients who have received a prior taxane and in patients with gemcitabine-refractory metastatic pancreatic cancer.

publication date

  • October 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-07-1218

PubMed ID

  • 17908977

Additional Document Info

start page

  • 5841

end page

  • 6

volume

  • 13

number

  • 19