Treatment of Hereditary Breast Cancer Review uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Breast Neoplasms
  • Genetic Predisposition to Disease

abstract

  • Mutations in BRCA1 and BRCA2 are well-established causes of hereditary breast cancer. As genetic testing becomes more widespread, increasing numbers of women are known to have mutations at or shortly after their breast cancer diagnosis. Current evidence is insufficient to mandate different local or systemic treatment based upon the presence of a germline mutation. The well-documented increased risk of contralateral second primary breast cancer and possibly of late ipsilateral second primary breast cancers may influence patient decision-making with regard to breast-conserving treatment.

publication date

  • October 2007

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1053/j.seminoncol.2007.07.011

PubMed ID

  • 17920892

Additional Document Info

start page

  • 384

end page

  • 91

volume

  • 34

number

  • 5