The role of cathelicidin and defensins in pulmonary inflammatory diseases. Review uri icon

Overview

MeSH

  • Animals
  • Humans

MeSH Major

  • Antimicrobial Cationic Peptides
  • Defensins
  • Pneumonia

abstract

  • Antimicrobial peptides (AMPs) protect the epithelia of mucosal organs like the respiratory or the gastrointestinal tract from invading microorganisms. As an integral part of the innate immune system they display antimicrobial activity against gram- and gram-negative bacteria as well as against fungi and enveloped and non-enveloped viruses. Besides their microbicidal effects they have important functions in the regulation of repair and inflammation. AMPs are sometimes referred to as 'alarmins' due to their ability to recruit, modulate and activate components of the immune system. In contrast, some AMPs suppress activation of the immune system. AMPs are also involved in tissue repair, cancer biology and angiogenesis. Based on their antimicrobial and immunomodulatoy functions, AMPs are probably involved in the pathogenesis of infectious and inflammatory diseases of the lung. Inborn or acquired deficiencies contribute to susceptibility to infection and colonisation. The potential pro-inflammatory role of AMPs contributes to the disease processes in inflammatory disorders such as asthma, chronic obstructive pulmonary disease, sepsis or pulmonary fibrosis. This review summarises the knowledge about the functions of AMPs in the pulmonary innate host defence system and their role in respiratory disease.

publication date

  • September 2007

has subject area

  • Animals
  • Antimicrobial Cationic Peptides
  • Defensins
  • Humans
  • Pneumonia

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1517/14712598.7.9.1449

PubMed ID

  • 17727333

Additional Document Info

start page

  • 1449

end page

  • 1461

volume

  • 7

number

  • 9