Gene expression in peripheral blood mononuclear cells from children with diabetes Academic Article uri icon

Overview

MeSH Major

  • Diabetes Mellitus
  • Gene Expression Profiling
  • Leukocytes, Mononuclear

abstract

  • T1D and T2D likely share a final common pathway for beta-cell dysfunction that includes secretion of IL-1beta and prostaglandins by immune effector cells, exacerbating existing beta-cell dysfunction, and causing further hyperglycemia. The results identify several targets for disease-modifying therapy of diabetes and potential biomarkers for monitoring treatment efficacy.

publication date

  • September 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1210/jc.2007-0979

PubMed ID

  • 17595242

Additional Document Info

start page

  • 3705

end page

  • 11

volume

  • 92

number

  • 9