Epigenetics in Apicomplexa: control of gene expression during cell cycle progression, differentiation and antigenic variation. Review uri icon

Overview

MeSH

  • Animals
  • Antigens, Protozoan
  • Cell Cycle
  • Humans

MeSH Major

  • Antigenic Variation
  • Apicomplexa
  • Epigenesis, Genetic
  • Gene Expression Regulation
  • Protozoan Infections

abstract

  • Apicomplexan parasites are important disease causing organisms that infect both animals and humans, causing extensive health and economic damage to human populations, particularly those in the developing world. The ability to perform genetic crosses, to engineer transgenic parasites lines, and the wealth of information made available through recent genome sequencing projects have made the laboratory study of these parasites important not only for understanding the diseases that they cause, but also for gaining insights into basic biological processes. The control of gene expression and cellular differentiation are particularly interesting in these organisms, as the apparent lack of large families of recognizable transcription factors typically found in other eukaryotic organisms suggests that they may be unusually reliant on epigenetic mechanisms. Here we review recent advances in the study of epigenetic gene regulation in the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii.

publication date

  • August 2007

has subject area

  • Animals
  • Antigenic Variation
  • Antigens, Protozoan
  • Apicomplexa
  • Cell Cycle
  • Epigenesis, Genetic
  • Gene Expression Regulation
  • Humans
  • Protozoan Infections

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.mib.2007.07.005

PubMed ID

  • 17719264

Additional Document Info

start page

  • 357

end page

  • 362

volume

  • 10

number

  • 4