Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis Academic Article uri icon

Overview

MeSH Major

  • Alleles
  • Breast Neoplasms
  • Genes, BRCA1
  • Genes, BRCA2
  • Loss of Heterozygosity

abstract

  • These data suggest that loss of the wild-type BRCA allele is not required for BRCA-linked breast tumorigenesis, which would have important implications for the genetic mechanism of BRCA tumor suppression and for the clinical management of this patient population.

publication date

  • September 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1245/s10434-007-9372-1

PubMed ID

  • 17597348

Additional Document Info

start page

  • 2510

end page

  • 8

volume

  • 14

number

  • 9