Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: Discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo Academic Article uri icon

Overview

MeSH Major

  • Autonomic Nervous System
  • Blood Pressure
  • Cardiovascular Diseases
  • Catecholamines
  • Transcription, Genetic
  • Tyrosine 3-Monooxygenase

abstract

  • We conclude that human catecholamine secretory traits are heritable, displaying joint genetic determination (pleiotropy) with autonomic activity and finally with blood pressure in the population. Catecholamine secretion is influenced by genetic variation in the adrenergic pathway encoding catecholamine synthesis, especially at the classically rate-limiting step, TH. The results suggest novel pathophysiological links between a key adrenergic locus, catecholamine metabolism, and blood pressure and suggest new strategies to approach the mechanism, diagnosis, and treatment of systemic hypertension.

publication date

  • August 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.106.682302

PubMed ID

  • 17698732

Additional Document Info

start page

  • 993

end page

  • 1006

volume

  • 116

number

  • 9