Ftm is a novel basal body protein of cilia involved in Shh signalling. Academic Article uri icon

Overview

MeSH

  • Animals
  • Cells, Cultured
  • Embryo, Mammalian
  • Extremities
  • Kruppel-Like Transcription Factors
  • Mice
  • Mice, Knockout
  • Mutation
  • Nerve Tissue Proteins
  • Neural Tube Defects
  • Phenotype
  • Polydactyly

MeSH Major

  • Adaptor Proteins, Signal Transducing
  • Body Patterning
  • Cilia
  • Hedgehog Proteins
  • Signal Transduction

abstract

  • In this study we show in mice that Ftm (Rpgrip1l) is located at the ciliary basal body. Our data reveal that Ftm is necessary for developmental processes such as the establishment of left-right asymmetry and patterning of the neural tube and the limbs. The loss of Ftm affects the ratio of Gli3 activator to Gli3 repressor, suggesting an involvement of Ftm in Shh signalling. As Ftm is not essential for cilia assembly but for full Shh response, Ftm can be considered as a novel component for cilium-related Hh signalling. Furthermore, the absence of Ftm in arthropods underlines the divergence between vertebrate and Drosophila Hh pathways.

publication date

  • July 2007

has subject area

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Body Patterning
  • Cells, Cultured
  • Cilia
  • Embryo, Mammalian
  • Extremities
  • Hedgehog Proteins
  • Kruppel-Like Transcription Factors
  • Mice
  • Mice, Knockout
  • Mutation
  • Nerve Tissue Proteins
  • Neural Tube Defects
  • Phenotype
  • Polydactyly
  • Signal Transduction

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1242/dev.003715

PubMed ID

  • 17553904

Additional Document Info

start page

  • 2569

end page

  • 2577

volume

  • 134

number

  • 14