CD39 activity correlates with stage and inhibits platelet reactivity in chronic lymphocytic leukemia
Leukemia, Lymphocytic, Chronic, B-Cell
CD39 is expressed and active on CLL cells. Enzyme activity is higher in earlier stages of CLL and decreased enzyme activity may be associated with worsening disease. These results suggest that CD39 may play a role in the pathogenesis of malignancy and protect CLL patients from thrombotic events.