Lipopolysaccharide induces early tolerance to excitotoxicity via nitric oxide and cGMP Academic Article uri icon

Overview

MeSH Major

  • Brain Diseases
  • Cyclic GMP
  • Ischemic Preconditioning
  • Lipopolysaccharides
  • Nitric Oxide

abstract

  • The data demonstrate that LPS induces both early and late tolerance. At variance with delayed tolerance, which depends on inducible NO synthase and peroxynitrite, early tolerance is mediated by endothelial and neuronal NO through production of cGMP. The findings suggest that LPS can trigger signaling between endothelial cells and neurons, leading to NO production and cGMP-dependent neuroprotection.

publication date

  • October 2007

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/STROKEAHA.107.486837

PubMed ID

  • 17761917

Additional Document Info

start page

  • 2812

end page

  • 7

volume

  • 38

number

  • 10