Interleukin-1 as a therapeutic target in systemic-onset juvenile idiopathic arthritis Report uri icon

Overview

MeSH Major

  • Autoimmune Diseases
  • Genes, Immunoglobulin
  • Immunoglobulin Variable Region

abstract

  • Systemic-onset juvenile idiopathic arthritis (SoJIA) represents up to 20% of chronic inflammatory arthritis cases in childhood. The clinical manifestations of this disease are unique compared with other forms of juvenile idiopathic arthritis, and many SoJIA patients do not respond to available therapies, including antitumor necrosis factor agents. It has recently been demonstrated that the serum of SoJIA patients contains an interleukin (IL)-1-inducing factor, and an excess of IL-1β is secreted upon activation of SoJIA leukocytes in vitro, suggesting that IL-1 might represent a potential therapeutic target in this disease. Indeed, administration of an IL-1 receptor antagonist induced clinical remission and corrected the laboratory abnormalities in a group of patients who had been refractory to conventional therapies, supporting the idea that IL-1 is an important mediator of the disease. © 2007 Future Medicine Ltd.

publication date

  • June 2007

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.2217/17460816.2.3.305

Additional Document Info

start page

  • 305

end page

  • 312

volume

  • 2

number

  • 3